PMID:19852855
| Citation |
Castaño-Cerezo, S, Pastor, JM, Renilla, S, Bernal, V, Iborra, JL and Cánovas, M (2009) An insight into the role of phosphotransacetylase (pta) and the acetate/acetyl-CoA node in Escherichia coli. Microb. Cell Fact. 8:54 |
|---|---|
| Abstract |
Acetate metabolism in Escherichia coli plays an important role in the control of the central metabolism and in bioprocess performance. The main problems related to the use of E. coli as cellular factory are i) the deficient utilization of carbon source due to the excretion of acetate during aerobic growth, ii) the inhibition of cellular growth and protein production by acetate and iii) the need for cofactor recycling (namely redox coenzymes and free CoASH) to sustain balanced growth and cellular homeostasis. |
| Links |
PubMed PMC2774668 Online version:10.1186/1475-2859-8-54 |
| Keywords |
Acetates/metabolism; Acetyl Coenzyme A/metabolism; Acetyl Coenzyme A/physiology; Biomass; Coenzyme A Ligases/genetics; Coenzyme A Ligases/metabolism; Coenzyme A Ligases/physiology; Escherichia coli/enzymology; Escherichia coli/growth & development; Gene Expression Profiling; Gene Knockout Techniques; Mutation; NAD/metabolism; Phosphate Acetyltransferase/genetics; Phosphate Acetyltransferase/metabolism; Phosphate Acetyltransferase/physiology |
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