PMID:1979037
| Citation |
Milkman, R and Bridges, MM (1990) Molecular evolution of the Escherichia coli chromosome. III. Clonal frames. Genetics 126:505-17 |
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| Abstract |
PCR fragments, 1500-bp, from 15 previously sequenced regions in the Escherichia coli chromosome have been compared by restriction analysis in a large set of wild (ECOR) strains. Prior published observations of segmental clonality are confirmed: each of several sequence types is shared by a number of strains. The rate of recombinational replacement and the average size of the replacements are estimated in a set of closely related strains in which a clonal frame is dotted with occasional stretches of DNA belonging to other clones. A clonal hierarchy is described. Some new comparative sequencing data are presented. |
| Links | |
| Keywords |
Base Sequence; Biological Evolution; Chromosomes, Bacterial; Cloning, Molecular; Escherichia coli/genetics; Operon; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Sequence Homology, Nucleic Acid |
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