PMID:1977738
| Citation |
Weaver, LM and Herrmann, KM (1990) Cloning of an aroF allele encoding a tyrosine-insensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase. J. Bacteriol. 172:6581-4 |
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| Abstract |
In Escherichia coli, genes aroF+, aroG+, and aroH+ encode isoenzymes of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthases that are feedback inhibited by tyrosine, phenylalanine, and tryptophan, respectively. A single base pair change in aroF causes a Pro-148-to-Leu-148 substitution and results in a tyrosine-insensitive enzyme. |
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| Keywords |
3-Deoxy-7-Phosphoheptulonate Synthase/genetics; 3-Deoxy-7-Phosphoheptulonate Synthase/metabolism; Alleles; Amino Acid Sequence; Base Sequence; Cloning, Molecular; Escherichia coli/enzymology; Escherichia coli/genetics; Genes, Bacterial; Isoenzymes/genetics; Isoenzymes/metabolism; Molecular Sequence Data; Plasmids; Restriction Mapping; Tyrosine/pharmacology |
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