PMID:19703305
| Citation |
Khankal, R, Chin, JW, Ghosh, D and Cirino, PC (2009) Transcriptional effects of CRP* expression in Escherichia coli. J Biol Eng 3:13 |
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| Abstract |
Escherichia coli exhibits diauxic growth in sugar mixtures due to CRP-mediated catabolite repression and inducer exclusion related to phosphotransferase system enzyme activity. Replacement of the native crp gene with a catabolite repression mutant (referred to as crp*) enables co-utilization of glucose and other sugars in E. coli. While previous studies have examined the effects of expressing CRP* mutants on the expression of specific catabolic genes, little is known about the global transcriptional effects of CRP* expression. In this study, we compare the transcriptome of E. coli W3110 (expressing wild-type CRP) to that of mutant strain PC05 (expressing CRP*) in the presence and absence of glucose. |
| Links |
PubMed PMC2743635 Online version:10.1186/1754-1611-3-13 |
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