PMID:19650909

Citation	Dong, T and Schellhorn, HE (2009) Global effect of RpoS on gene expression in pathogenic Escherichia coli O157:H7 strain EDL933. BMC Genomics 10:349
Abstract	RpoS is a conserved stress regulator that plays a critical role in survival under stress conditions in Escherichia coli and other gamma-proteobacteria. RpoS is also involved in virulence of many pathogens including Salmonella and Vibrio species. Though well characterized in non-pathogenic E. coli K12 strains, the effect of RpoS on transcriptome expression has not been examined in pathogenic isolates. E. coli O157:H7 is a serious human enteropathogen, possessing a genome 20% larger than that of E. coli K12, and many of the additional genes are required for virulence. The genomic difference may result in substantial changes in RpoS-regulated gene expression. To test this, we compared the transcriptional profile of wild type and rpoS mutants of the E. coli O157:H7 EDL933 type strain.
Links	PubMed PMC2907692 Online version:10.1186/1471-2164-10-349
Keywords	Bacterial Proteins/genetics; Culture Media; Escherichia coli O157/genetics; Escherichia coli O157/growth & development; Escherichia coli O157/metabolism; Escherichia coli Proteins/genetics; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Gene Regulatory Networks; Oligonucleotide Array Sequence Analysis; RNA, Bacterial/genetics; Regulon; Sequence Deletion; Sigma Factor/genetics; Stress, Physiological
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