PMID:1958130
| Citation |
Seidel, W, Künkel, F, Geisler, B, Garten, W, Herrmann, B, Döhner, L and Klenk, HD (1991) Intraepidemic variants of influenza virus H3 hemagglutinin differing in the number of carbohydrate side chains. Arch. Virol. 120:289-96 |
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| Abstract |
During the epidemic outbreak in the region of Greifswald in the winter 1974/75, we found influenza virus variants which showed differences in the electrophoretic mobility of HA. Among the 25 isolates 13 were of slower and 12 of higher mobility. HA1 of 6 isolates was studied by determining the number of the carbohydrate side chains and by direct sequencing of vRNA. Evidence is presented that variants showing a slower electrophoretic mobility of HA1 had consistently acquired a seventh carbohydrate side chain at Asn 126 in epitope A. All the isolates differed from the reference strain A/Port Chalmers/1/73 by the loss of the oligosaccharide at Asn 81. The field strain A/Dresden/3/71 possessed only 5 oligosaccharides in HA1. These results suggest that changes in glycosylation are an important mechanism in the structural variation underlying antigenic drift of HA. |
| Links | |
| Keywords |
Antigenic Variation; Disease Outbreaks; Electrophoresis, Polyacrylamide Gel; Glycosylation; Hemagglutinin Glycoproteins, Influenza Virus; Hemagglutinins, Viral/chemistry; Hemagglutinins, Viral/genetics; Hemagglutinins, Viral/immunology; Humans; Influenza A virus/genetics; Influenza A virus/immunology; Influenza, Human/epidemiology; Influenza, Human/microbiology; Oligosaccharides/analysis |
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