PMID:1938967

Citation	Sarsero, JP and Pittard, AJ (1991) Molecular analysis of the TyrR protein-mediated activation of mtr gene expression in Escherichia coli K-12. J. Bacteriol. 173:7701-4
Abstract	Expression of the mtr gene, which encodes a tryptophan-specific transport system in Escherichia coli K-12, is activated by the TyrR protein. Two TyrR protein binding sites (TYR R boxes) are positioned upstream of the -35 promoter region. Mutational and DNase protection studies indicate that TyrR protein binds preferentially to the TYR R box closest to the promoter, and this is essential for activation of gene expression. In the presence of tyrosine and ATP, a second TyrR molecule is able to cooperatively bind to the second box and cause a further increase in the level of activation.
Links	PubMed PMC212541
Keywords	Amino Acid Sequence; Base Sequence; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Membrane Proteins/genetics; Membrane Proteins/metabolism; Molecular Sequence Data; Mutagenesis, Site-Directed; Plasmids; Recombinant Proteins/metabolism; Repressor Proteins/genetics; Repressor Proteins/metabolism; Transcription Factors/metabolism; Tryptophan/metabolism; Tyrosine/metabolism; beta-Galactosidase/genetics; beta-Galactosidase/metabolism
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