PMID:19366454
| Citation |
Zare, H, Sangurdekar, D, Srivastava, P, Kaveh, M and Khodursky, A (2009) Reconstruction of Escherichia coli transcriptional regulatory networks via regulon-based associations. BMC Syst Biol 3:39 |
|---|---|
| Abstract |
Network reconstruction methods that rely on covariance of expression of transcription regulators and their targets ignore the fact that transcription of regulators and their targets can be controlled differently and/or independently. Such oversight would result in many erroneous predictions. However, accurate prediction of gene regulatory interactions can be made possible through modeling and estimation of transcriptional activity of groups of co-regulated genes. |
| Links |
PubMed PMC2689187 Online version:10.1186/1752-0509-3-39 |
| Keywords |
Algorithms; Analysis of Variance; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins/metabolism; Gene Expression Profiling; Gene Expression Regulation, Bacterial/genetics; Gene Regulatory Networks; Models, Genetic; Normal Distribution; Oligonucleotide Array Sequence Analysis; Regulon/genetics; Sensitivity and Specificity; Transcription Factors/metabolism; Transcription, Genetic/genetics |
| edit table |
Significance
You can help EcoliWiki by summarizing why this paper is useful
Useful Materials and Methods
You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.
Annotations
<annotationlinks/>
EcoliWiki Links
Add links to pages that link here (e.g. gene, product, method pages)
See also
References
See Help:References for how to manage references in EcoliWiki.