PMID:19261481
| Citation |
Mizusawa, K, Abe, K, Sando, S and Aoyama, Y (2009) Synthesis of puromycin derivatives with backbone-elongated substrates and associated translation inhibitory activities. Bioorg. Med. Chem. 17:2381-7 |
|---|---|
| Abstract |
We have synthesized a series of 5'-phosphorylated and 5'-cytidylyl-(3'-5')-cytidylyl-(3'-5')-puromycin derivatives that have backbone-elongated substrates. All the synthesized puromycin derivatives showed good solubility in water and were applied to translation inhibitory assay in a reconstituted Escherichia coli translation system. |
| Links |
PubMed Online version:10.1016/j.bmc.2009.02.006 |
| Keywords |
Chromatography, High Pressure Liquid; Escherichia coli/genetics; Phosphorylation; Protein Biosynthesis/drug effects; Puromycin/chemical synthesis; Puromycin/chemistry; Puromycin/pharmacology; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization |
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