PMID:19154575

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Citation

Dabrowska, K, Skaradziński, G, Jończyk, P, Kurzepa, A, Wietrzyk, J, Owczarek, B, Zaczek, M, Switała-Jeleń, K, Boratyński, J, Poźniak, G, Maciejewska, M and Górski, A (2009) The effect of bacteriophages T4 and HAP1 on in vitro melanoma migration. BMC Microbiol. 9:13

Abstract

The antibacterial activity of bacteriophages has been described rather well. However, knowledge about the direct interactions of bacteriophages with mammalian organisms and their other, i.e. non-antibacterial, activities in mammalian systems is quite scarce. It must be emphasised that bacteriophages are natural parasites of bacteria, which in turn are parasites or symbionts of mammals (including humans). Bacteriophages are constantly present in mammalian bodies and the environment in great amounts. On the other hand, the perspective of the possible use of bacteriophage preparations for antibacterial therapies in cancer patients generates a substantial need to investigate the effects of phages on cancer processes.

Links

PubMed PMC2639589 Online version:10.1186/1471-2180-9-13

Keywords

Animals; Bacteriophage T4/physiology; Cell Line, Tumor; Cell Movement; Collagen/metabolism; Drug Combinations; Fibronectins/metabolism; Humans; Laminin/metabolism; Lipopolysaccharides/metabolism; Mice; Proteoglycans/metabolism

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