PMID:1906969

Citation	Lerner, CG and Inouye, M (1991) Pleiotropic changes resulting from depletion of Era, an essential GTP-binding protein in Escherichia coli. Mol. Microbiol. 5:951-7
Abstract	Phenotypic analysis of a temperature-sensitive era mutant strain indicates that Escherichia coli cells depleted of Era undergo many physiological changes. At 43 degrees C, a completely non-permissive temperature, growth is arrested because of loss of the gene and depletion of the Era protein. Depletion of Era at 43 degrees C results in depressed synthesis of heat-shock proteins DnaK, GroEL/ES, D33.4 and C62.5, lack of thermal induction of ppGpp pool levels, and increased capacity for carbon source metabolism through the citric acid cycle. Thus, in addition to inhibition of cell growth and viability, loss of Era function results in pleiotropic changes including abnormal adaptation to thermal stress.
Links	PubMed
Keywords	Bacterial Proteins/metabolism; Cell Division; Citric Acid Cycle; Electrophoresis, Gel, Two-Dimensional; Escherichia coli/genetics; Escherichia coli/physiology; Escherichia coli Proteins; GTP-Binding Proteins/metabolism; Guanosine Tetraphosphate/biosynthesis; Heat-Shock Proteins/biosynthesis; Kinetics; Mutation; Phenotype; Plasmids/genetics; RNA-Binding Proteins; Temperature
edit table

Significance

You can help EcoliWiki by summarizing why this paper is useful

You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.

Add links to pages that link here (e.g. gene, product, method pages)

See Help:References for how to manage references in EcoliWiki.