PMID:1877385
| Citation |
Benner, SA and Gerloff, D (1991) Patterns of divergence in homologous proteins as indicators of secondary and tertiary structure: a prediction of the structure of the catalytic domain of protein kinases. Adv. Enzyme Regul. 31:121-81 |
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| Abstract |
The secondary structure and elements of tertiary structure have been predicted for the catalytic domain of protein kinases using a method that extracts structural information from the patterns of conservation and variation in an alignment of homologous proteins. The central features of this structural prediction are: (a) the catalytic domains of protein kinases do not incorporate a Rossmann fold; (b) the core of the structure is founded on beta sheets built from pairs of bent antiparallel beta strands; (c) five helices, including an especially long helix (alignment positions 129-152) that lie on the outside of the folded core. These proteins are important in many aspects of metabolic regulation. |
| Links | |
| Keywords |
Animals; Base Sequence; Binding Sites; Genetic Variation; Humans; Protein Conformation; Protein Kinases/chemistry; Protein Kinases/genetics; Sequence Homology, Nucleic Acid |
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