PMID:1872800
| Citation |
Weitkamp, EL, Dixon, HB, Khomutov, AR and Khomutov, RM (1991) Effect of magnesium ions on the inhibition of S-adenosylmethionine decarboxylase from Escherichia coli by [2-(amino-oxy)ethyl](5'-deoxyadenosin-5'-yl)(methyl)sulphonium . Biochem. J. 277 ( Pt 3):643-5 |
|---|---|
| Abstract |
[2-(Amino-oxy)ethyl](5'-deoxyadenosin-5'-yl)(methyl)sulphonium+ ++, the amino-oxy analogue of decarboxylated S-adenosylmethionine, is a potent irreversible inhibitor of Escherichia coli S-adenosylmethionine decarboxylase [Khomutov, Zavalova, Syrku, Artamonova & Khomutov (1983) Bioorg. Khim. 9, 130-131; Artamonova, Zavalova, Khomutov & Khomutov (1986) Bioorg. Khim. 12, 206-212]. We have shown that Mg2+ ions are required for the irreversible inhibition of the decarboxylase, and that S-adenosylmethionine protects against this inhibition. |
| Links | |
| Keywords |
Adenosylmethionine Decarboxylase/antagonists & inhibitors; Deoxyadenosines/pharmacology; Escherichia coli/enzymology; Magnesium/pharmacology; Protein Binding; S-Adenosylmethionine/metabolism |
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