PMID:18475267

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Citation

Rhee, SY, Wood, V, Dolinski, K and Draghici, S (2008) Use and misuse of the gene ontology annotations. Nat. Rev. Genet. 9:509-15

Abstract

The Gene Ontology (GO) project is a collaboration among model organism databases to describe gene products from all organisms using a consistent and computable language. GO produces sets of explicitly defined, structured vocabularies that describe biological processes, molecular functions and cellular components of gene products in both a computer- and human-readable manner. Here we describe key aspects of GO, which, when overlooked, can cause erroneous results, and address how these pitfalls can be avoided.

Links

PubMed Online version:10.1038/nrg2363

Keywords

Computational Biology; Databases, Genetic; Humans; Natural Language Processing; Proteins/genetics; Proteins/metabolism; Software

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