PMID:18406319

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Citation

Ellis, T, Wang, X and Collins, JJ (2008) Gene regulation: hacking the network on a sugar high. Mol. Cell 30:1-2

Abstract

In a recent issue of Molecular Cell, Kaplan et al. (2008) determine the input functions for 19 E. coli sugar-utilization genes by using a two-dimensional high-throughput approach. The resulting input-function map reveals that gene network regulation follows non-Boolean, and often nonmonotonic, logic.

Links

PubMed Online version:10.1016/j.molcel.2008.03.005

Keywords

Carbohydrates; Cyclic AMP/metabolism; Escherichia coli/genetics; Escherichia coli/metabolism; Gene Expression Regulation; Gene Regulatory Networks; Genes, Reporter; Logic; Promoter Regions, Genetic

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