PMID:1838215
| Citation |
Böck, A, Forchhammer, K, Heider, J and Baron, C (1991) Selenoprotein synthesis: an expansion of the genetic code. Trends Biochem. Sci. 16:463-7 |
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| Abstract |
A number of enzymes employ the unusual amino acid selenocysteine as part of their active site because of its high chemical reactivity. Selenocysteine is incorporated into these proteins co-translationally: biosynthesis occurs on a specific tRNA and insertion into a growing polypeptide is directed by a UGA codon in the mRNA. In E. coli, this requires a specific translation factor. Selenocysteine thus represents a unique expansion of the genetic code. |
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| Keywords |
Animals; Base Sequence; Codon; Cysteine/analogs & derivatives; Cysteine/biosynthesis; Cysteine/genetics; Escherichia coli/genetics; Genetic Code; Humans; Molecular Sequence Data; Organoselenium Compounds; Protein Biosynthesis; Proteins/genetics; RNA, Messenger/genetics; RNA, Transfer, Amino Acid-Specific/genetics; Selenium/metabolism; Selenocysteine; Selenoproteins |
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