PMID:18326572
| Citation |
Richard-Fogal, CL, Frawley, ER and Kranz, RG (2008) Topology and function of CcmD in cytochrome c maturation. J. Bacteriol. 190:3489-93 |
|---|---|
| Abstract |
The system I cytochrome c biogenesis pathway requires CcmD, a small polypeptide of 69 residues in Escherichia coli. Here it is shown that CcmD is a component of the CcmABC ATP-binding cassette transporter complex. CcmD is not necessary for the CcmC-dependent transfer of heme to CcmE in the periplasm or for interaction of CcmE with CcmABC. CcmD is absolutely required for the release of holo-CcmE from the CcmABCD complex. Evidence is presented that the topology of CcmD in the cytoplasmic membrane is the N terminus outside and the C terminus inside with one transmembrane domain. |
| Links |
PubMed PMC2394986 Online version:10.1128/JB.00146-08 |
| Keywords |
ATP-Binding Cassette Transporters; Bacterial Proteins/chemistry; Bacterial Proteins/metabolism; Bacterial Proteins/physiology; Biological Transport; Cell Membrane; Cytochromes c/biosynthesis; Cytochromes c/chemistry; Cytochromes c/metabolism; Escherichia coli/genetics; Escherichia coli/growth & development; Escherichia coli/metabolism; Escherichia coli Proteins/chemistry; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Genes, Bacterial; Membrane Proteins/chemistry; Membrane Proteins/genetics; Membrane Proteins/metabolism; Membrane Proteins/physiology |
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