PMID:18302792
| Citation |
Kannan, G, Wilks, JC, Fitzgerald, DM, Jones, BD, Bondurant, SS and Slonczewski, JL (2008) Rapid acid treatment of Escherichia coli: transcriptomic response and recovery. BMC Microbiol. 8:37 |
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| Abstract |
Many E. coli genes show pH-dependent expression during logarithmic growth in acid (pH 5-6) or in base (pH 8-9). The effect of rapid pH change, however, has rarely been tested. Rapid acid treatment could distinguish between genes responding to external pH, and genes responding to cytoplasmic acidification, which occurs transiently following rapid external acidification. It could reveal previously unknown acid-stress genes whose effects are transient, as well as show which acid-stress genes have a delayed response. |
| Links |
PubMed PMC2270276 Online version:10.1186/1471-2180-8-37 |
| Keywords |
Acids; Escherichia coli K12/genetics; Escherichia coli Proteins/genetics; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Hydrogen-Ion Concentration; Oligonucleotide Array Sequence Analysis |
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