PMID:18236183

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Citation

Dunne, N, Hill, J, McAfee, P, Todd, K, Kirkpatrick, R, Tunney, M and Patrick, S (2007) In vitro study of the efficacy of acrylic bone cement loaded with supplementary amounts of gentamicin: effect on mechanical properties, antibiotic release, and biofilm formation. Acta Orthop 78:774-85

Abstract

Infection remains a severe complication following a total hip replacement. If infection is suspected when revision surgery is being performed, additional gentamicin is often added to the cement on an ad hoc basis in an attempt to reduce the risk of recurrent infection.

Links

PubMed Online version:10.1080/17453670710014545

Keywords

Acrylic Resins; Anti-Bacterial Agents/administration & dosage; Anti-Bacterial Agents/pharmacokinetics; Bacterial Adhesion/drug effects; Biofilms/drug effects; Bone Cements; Gentamicins/administration & dosage; Gentamicins/pharmacokinetics; Humans; Prosthesis Failure; Prosthesis-Related Infections/microbiology; Prosthesis-Related Infections/prevention & control; Staphylococcus/drug effects; Staphylococcus/isolation & purification; Stress, Mechanical; Time Factors

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