PMID:18236139
| Citation |
Deng, JW, Shon, JH, Shin, HJ, Park, SJ, Yeo, CW, Zhou, HH, Song, IS and Shin, JG (2008) Effect of silymarin supplement on the pharmacokinetics of rosuvastatin. Pharm. Res. 25:1807-14 |
|---|---|
| Abstract |
To evaluate the effect of silymarin on the pharmacokinetics of rosuvastatin in systems overexpressing OATP1B1 or BCRP transporters and in healthy subjects. |
| Links |
PubMed Online version:10.1007/s11095-007-9492-0 |
| Keywords |
ATP-Binding Cassette Transporters/metabolism; Adult; Algorithms; Antioxidants/pharmacology; Area Under Curve; Biological Transport, Active/drug effects; Cell Line, Tumor; Cross-Over Studies; Dietary Supplements/adverse effects; Drug Interactions; Female; Fluorobenzenes/pharmacokinetics; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacokinetics; Male; Neoplasm Proteins/metabolism; Organic Anion Transporters/metabolism; Pyrimidines/pharmacokinetics; Silymarin/pharmacology; Sulfonamides/pharmacokinetics |
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