PMID:18236015
| Citation |
Sekiguchi, F, Takaoka, K and Kawabata, A (2007) Proteinase-activated receptors in the gastrointestinal system: a functional linkage to prostanoids. Inflammopharmacology 15:246-51 |
|---|---|
| Abstract |
Proteinase-activated receptors (PARs), G protein-coupled receptors, play critical roles in the alimentary system. Increasing evidence suggests that endogenous prostaglandins (PGs) mediate some of PARs' gastrointestinal functions. Systemic administration of the PAR1 agonist protects against gastric mucosal injury through PG formation in rats. PGs also appear to contribute, at least in part, to enhancement of gastric mucosal blood flow and suppression of gastric acid secretion by PAR1 activation. There is also evidence for involvement of PGs in modulation of gastrointestinal motility by PAR1 or PAR2. Importantly, modulation of ion transport by PAR1 or PAR2 in the intestinal mucosal epithelium is largely mediated by PGs. Studies using gastric and intestinal mucosal epithelial cell lines imply that the PAR1-triggered formation of PGs involves multiple signaling pathways including Src, EGF receptor trans-activation and activation of MAP kinases. Collectively, a functional linkage of PAR1 and/or PAR2 to PGs is considered important in the gastrointestinal system. |
| Links |
PubMed Online version:10.1007/s10787-007-1591-3 |
| Keywords |
Animals; Digestive System; Dinoprostone/biosynthesis; Gastric Mucosa/metabolism; Gastrointestinal Tract/physiology; Humans; Intestinal Mucosa/cytology; Intestinal Mucosa/metabolism; Prostaglandins/physiology; Receptor, PAR-1/physiology; Receptor, PAR-2/physiology; Receptors, Proteinase-Activated/physiology |
| edit table |
Significance
You can help EcoliWiki by summarizing why this paper is useful
Useful Materials and Methods
You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.
Annotations
<annotationlinks/>
EcoliWiki Links
Add links to pages that link here (e.g. gene, product, method pages)
References
See Help:References for how to manage references in EcoliWiki.