PMID:18235020

Citation	Yuan, Z, Hein, TW, Rosa, RH Jr and Kuo, L (2008) Sildenafil (Viagra) evokes retinal arteriolar dilation: dual pathways via NOS activation and phosphodiesterase inhibition. Invest. Ophthalmol. Vis. Sci. 49:720-5
Abstract	Sildenafil (Viagra; Pfizer, New York, NY), a selective phosphodiesterase type-5 (PDE5) inhibitor, is widely used to treat impotence by improving penile blood flow via elevation of cGMP. However, its effect on ocular circulation is controversial and whether retinal arterioles are responsive to this drug remains unclear. In this study, the direct reaction of retinal arterioles to sildenafil was examined and the signaling pathway underlying this vasomotor activity was probed.
Links	PubMed Online version:10.1167/iovs.07-1208
Keywords	3',5'-Cyclic-GMP Phosphodiesterases/antagonists & inhibitors; Animals; Arterioles/physiology; Dose-Response Relationship, Drug; Enzyme Inhibitors/pharmacology; Extracellular Signal-Regulated MAP Kinases/metabolism; Female; Guanylate Cyclase/metabolism; KATP Channels/metabolism; Male; Nitric Oxide/biosynthesis; Nitric Oxide Synthase Type III/metabolism; Phosphodiesterase Inhibitors/pharmacology; Piperazines/pharmacology; Purines/pharmacology; Retinal Artery/physiology; Signal Transduction; Sulfones/pharmacology; Swine; Vasodilation/physiology; Vasodilator Agents/pharmacology; Vasomotor System/drug effects
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