PMID:18234993
| Citation |
Farjo, R, Peterson, WM and Naash, MI (2008) Expression profiling after retinal detachment and reattachment: a possible role for aquaporin-0. Invest. Ophthalmol. Vis. Sci. 49:511-21 |
|---|---|
| Abstract |
Retinal detachment (RD) is associated with acute visual loss caused by anatomic displacement of the photoreceptors and with chronic visual loss/disturbance caused by retinal remodeling and photoreceptor cell death, which may occur even after successful reattachment. The P2Y(2) receptor agonist INS37217 improves the rate of retinal reattachment in animal models of induced RD, and has been shown to also significantly enhance the rate of ERG recovery in a mouse model of RD. The identification of genes modulated by INS37217 may allow further drug discovery for treating RD and edema. |
| Links |
PubMed PMC2792233 Online version:10.1167/iovs.07-1013 |
| Keywords |
Animals; Aquaporins/genetics; Deoxycytosine Nucleotides/pharmacology; Disease Models, Animal; Electroretinography; Eye Proteins/genetics; Fluorescent Antibody Technique, Indirect; Gene Expression Profiling; Gene Expression Regulation/drug effects; Gene Expression Regulation/physiology; Immunoblotting; Immunoprecipitation; Membrane Glycoproteins/genetics; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; RNA, Messenger/metabolism; Retinal Detachment/genetics; Retinal Detachment/physiopathology; Retinal Detachment/surgery; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation; Uridine/analogs & derivatives; Uridine/pharmacology |
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