PMID:18234991

Citation	Ye, M, Hu, D, Tu, L, Zhou, X, Lu, F, Wen, B, Wu, W, Lin, Y, Zhou, Z and Qu, J (2008) Involvement of PI3K/Akt signaling pathway in hepatocyte growth factor-induced migration of uveal melanoma cells. Invest. Ophthalmol. Vis. Sci. 49:497-504
Abstract	Uveal melanoma is the most common primary intraocular malignancy in adult humans. Unlike cutaneous melanoma, uveal melanoma disseminates preferentially to the liver through the hematogenous system. To date, the mechanism underlying this metastatic homing is largely unknown. This study investigated the effect of hepatocyte growth factor (HGF)-triggered signaling pathways to identify the role of HGF and its downstream effectors in inducing the migration of uveal melanoma cells.
Links	PubMed Online version:10.1167/iovs.07-0975
Keywords	Blotting, Western; Cadherins/metabolism; Cell Adhesion/drug effects; Cell Movement/drug effects; Cell Nucleus/metabolism; Down-Regulation; Fluorescent Antibody Technique, Indirect; Hepatocyte Growth Factor/pharmacology; Humans; Melanoma/metabolism; Melanoma/pathology; Microscopy, Confocal; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Proto-Oncogene Proteins c-met/metabolism; Signal Transduction/drug effects; Tumor Cells, Cultured; Uveal Neoplasms/metabolism; Uveal Neoplasms/pathology; Wound Healing; beta Catenin/metabolism
edit table

Significance

You can help EcoliWiki by summarizing why this paper is useful

You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.

Add links to pages that link here (e.g. gene, product, method pages)

See Help:References for how to manage references in EcoliWiki.