PMID:18234309

Citation	Mrabet-Dahbi, S, Dalpke, AH, Niebuhr, M, Frey, M, Draing, C, Brand, S, Heeg, K, Werfel, T and Renz, H (2008) The Toll-like receptor 2 R753Q mutation modifies cytokine production and Toll-like receptor expression in atopic dermatitis. J. Allergy Clin. Immunol. 121:1013-9
Abstract	Impaired host defense mechanisms may crucially modulate the pathogenesis of atopic dermatitis (AD). More than 10% of patients with AD are heterozygous for the Toll-like receptor 2 (TLR-2) R753Q single nucleotide polymorphism (SNP) and exhibit severe eczema.
Links	PubMed Online version:10.1016/j.jaci.2007.11.029
Keywords	Amino Acid Substitution/genetics; Amino Acid Substitution/immunology; Arginine/genetics; Cell Line; Cytokines/antagonists & inhibitors; Cytokines/biosynthesis; Dermatitis, Atopic/genetics; Dermatitis, Atopic/immunology; Dermatitis, Atopic/metabolism; Gene Expression Regulation/immunology; Glutamine/genetics; Heterozygote Detection; Humans; Immunity, Innate/genetics; Mutagenesis, Site-Directed; Mutation; Polymorphism, Single Nucleotide; RNA, Messenger/biosynthesis; Toll-Like Receptor 2/antagonists & inhibitors; Toll-Like Receptor 2/biosynthesis; Toll-Like Receptor 2/genetics; Toll-Like Receptor 2/physiology; Toll-Like Receptor 6/biosynthesis; Toll-Like Receptor 6/genetics
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