PMID:18234293

Citation	Wallin, R, Schurgers, L and Wajih, N (2008) Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification. Thromb. Res. 122:411-7
Abstract	The transformation of smooth muscle cells (VSMCs) in the vessel wall to osteoblast like cells is known to precede arterial calcification which may cause bleeding complications. The vitamin K-dependent protein MGP has been identified as an inhibitor of this process by binding BMP-2, a growth factor known to trigger the transformation. In this study, we determined if the vitamin K-dependent Gla region in MGP by itself can inhibit the growth factor activity of BMP-2 and if menaquinone-4 (MK4) regulates gene expression in VSMCs.
Links	PubMed PMC2529147 Online version:10.1016/j.thromres.2007.12.005
Keywords	Animals; Antifibrinolytic Agents/pharmacology; Aorta, Thoracic/cytology; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins/metabolism; Calcinosis/pathology; Calcinosis/prevention & control; Calcium-Binding Proteins/pharmacology; Cell Differentiation/drug effects; Cell Line; Extracellular Matrix Proteins/pharmacology; Humans; Mice; Muscle, Smooth, Vascular/cytology; Muscle, Smooth, Vascular/drug effects; Myoblasts/cytology; Osteoblasts/cytology; Peptide Fragments/pharmacology; Rats; Transforming Growth Factor beta/metabolism; Vitamin K/pharmacology; Vitamin K 2/analogs & derivatives; Vitamin K 2/pharmacology
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