PMID:18233493

Citation	Audit, B, Nicolay, S, Huvet, M, Touchon, M, d'Aubenton-Carafa, Y, Thermes, C and Arneodo, A (2007) DNA replication timing data corroborate in silico human replication origin predictions. Phys. Rev. Lett. 99:248102
Abstract	We develop a wavelet-based multiscale pattern recognition methodology to disentangle the replication- from the transcription-associated compositional strand asymmetries observed in the human genome. Comparing replication skew profiles to recent high-resolution replication timing data reveals that most of the putative replication origins that border the so-identified replication domains are replicated earlier than their surroundings whereas the central regions replicate late in the S phase. We discuss the implications of this first experimental confirmation of these replication origin predictions that are likely to be early replicating and active in most tissues.
Links	PubMed
Keywords	Animals; DNA Replication; Genome, Human; Humans; Models, Genetic; Pattern Recognition, Automated/methods
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