PMID:18233044
| Citation |
Aguirre, J and Manrubia, SC (2008) Effects of spatial competition on the diversity of a quasispecies. Phys. Rev. Lett. 100:038106 |
|---|---|
| Abstract |
The diversity harbored by populations of RNA viruses results from high mutation rates, as well as from the characteristics of the environment where they evolve. By means of a simple model for structured quasispecies, we quantify how competition for space among phenotypic types shapes their distribution at the mutation-selection equilibrium. We introduce a general framework to treat this problem and relate mutation rate and competition strength to the quasispecies composition. For diffusion limited competition, diversity typically increases and the asymptotic growth rate of the population diminishes as diffusion decreases. Limited mobility confers a relative advantage to worse competitors. The stationary state is characterized by an over-production of viral particles. Empirical data allow an estimation of mutation rates compatible with the diversity observed in viral populations infecting cellular monolayers. |
| Links | |
| Keywords |
Models, Biological; Models, Genetic; Mutation; RNA Viruses/genetics; RNA Viruses/growth & development; RNA Viruses/physiology |
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