PMID:18231579

Citation	Gerber, HB, Pikman, Y and Fisher, RP (2008) The CDK-activating kinase (CAK) Csk1 is required for normal levels of homologous recombination and resistance to DNA damage in fission yeast. PLoS ONE 3:e1492
Abstract	Cyclin-dependent kinases (CDKs) perform essential roles in cell division and gene expression in all eukaryotes. The requirement for an upstream CDK-activating kinase (CAK) is also universally conserved, but the fission yeast Schizosaccharomyces pombe appears to be unique in having two CAKs with both overlapping and specialized functions that can be dissected genetically. The Mcs6 complex--orthologous to metazoan Cdk7/cyclin H/Mat1--activates the cell-cycle CDK, Cdk1, but its non-redundant essential function appears to be in regulation of gene expression, as part of transcription factor TFIIH. The other CAK is Csk1, an ortholog of budding yeast Cak1, which activates all three essential CDKs in S. pombe--Cdk1, Mcs6 and Cdk9, the catalytic subunit of positive transcription elongation factor b (P-TEFb)--but is not itself essential.
Links	PubMed PMC2200797 Online version:10.1371/journal.pone.0001492
Keywords	DNA Damage; Protein Kinases/metabolism; Recombination, Genetic; Schizosaccharomyces/genetics; Schizosaccharomyces pombe Proteins/metabolism
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