PMID:18227827
| Citation |
Cole, ME, Broaddus, R, Thaker, P, Landen, C and Freedman, RS (2008) Placental-site trophoblastic tumors: a case of resistant pulmonary metastasis. Nat Clin Pract Oncol 5:171-5 |
|---|---|
| Abstract |
Background A 52-year-old woman whose last known pregnancy was 12 years before presentation was diagnosed with mixed trophoblastic tumor that included placental-site trophoblastic tumor, epithelioid trophoblastic tumor, and focal choriocarcinoma. There was no clear evidence of metastatic disease on initial evaluation. Investigations Histopathology, laboratory tests, immunohistochemistry, chest X-ray, CT scan of the chest, abdomen, and pelvis, fine-needle aspiration biopsy, PET-CT scan.Diagnosis Metastatic chemoresistant placental-site trophoblastic tumor positive for EGFR, VEGF receptor, and platelet-derived growth factor receptor. Management Abdominal hysterectomy, bilateral salpingo-oophorectomy, pelvic radiation, etoposide, methotrexate, actinomycin D/cyclophosphamide and vincristine chemotherapy, left thoracotomy with wedge resection, taxol, etoposide, cisplatin therapy, right thoracotomy with wedge resection. |
| Links |
PubMed Online version:10.1038/ncponc1042 |
| Keywords |
Combined Modality Therapy; Drug Resistance, Neoplasm; Female; Humans; Lung Neoplasms/pathology; Lung Neoplasms/secondary; Lung Neoplasms/therapy; Middle Aged; Mixed Tumor, Malignant/pathology; Mixed Tumor, Malignant/secondary; Mixed Tumor, Malignant/therapy; Pregnancy; Trophoblastic Tumor, Placental Site/pathology; Trophoblastic Tumor, Placental Site/secondary; Trophoblastic Tumor, Placental Site/therapy; Uterine Neoplasms/pathology; Uterine Neoplasms/therapy |
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