PMID:18225534
| Citation |
Das, JR, Fryar-Tita, EB, Zhou, Y, Green, S, Southerland, WM and Bowen, D Sequence-dependent administration of 5-fluorouracil maintains methotrexate antineoplastic activity in human estrogen-negative breast cancer and protects against methotrexate cytotoxicity in human bone marrow. Anticancer Res. 27:3791-9 |
|---|---|
| Abstract |
Breast cancer is a leading cause of morbidity and mortality in women in developed countries and in increasingly developing countries. In general, estrogen receptor (ER)-positive breast cancers have a better prognosis and are often more responsive to anti-estrogen therapy. Unfortunately, ER-negative breast cancers are more aggressive and unresponsive to anti-estrogens. The aim of this investigation was to evaluate the 5-fluorouracil (5-FU) and methotrexate (MTX) combination to determine the most effective regimen considering the mechanism of action in treating ER-negative human breast cancer cells and at the same time mitigating methotrexate cytotoxicity in human bone marrow cells. |
| Links | |
| Keywords |
Antineoplastic Combined Chemotherapy Protocols/administration & dosage; Antineoplastic Combined Chemotherapy Protocols/adverse effects; Apoptosis/drug effects; Blotting, Western; Bone Marrow Cells/drug effects; Bone Marrow Cells/pathology; Bone Marrow Diseases/chemically induced; Bone Marrow Diseases/prevention & control; Breast Neoplasms/drug therapy; Breast Neoplasms/metabolism; Breast Neoplasms/pathology; Cell Cycle/drug effects; Cell Growth Processes/drug effects; Cell Line, Tumor; Drug Administration Schedule; Drug Interactions; Fluorouracil/administration & dosage; Fluorouracil/adverse effects; Humans; Methotrexate/administration & dosage; Methotrexate/adverse effects; Receptors, Estrogen/metabolism |
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