PMID:18217182
| Citation |
Pomeroy, LW, Bjørnstad, ON and Holmes, EC (2008) The evolutionary and epidemiological dynamics of the paramyxoviridae. J. Mol. Evol. 66:98-106 |
|---|---|
| Abstract |
Paramyxoviruses are responsible for considerable disease burden in human and wildlife populations: measles and mumps continue to affect the health of children worldwide, while canine distemper virus causes serious morbidity and mortality in a wide range of mammalian species. Although these viruses have been studied extensively at both the epidemiological and the phylogenetic scales, little has been done to integrate these two types of data. Using a Bayesian coalescent approach, we infer the evolutionary and epidemiological dynamics of measles, mumps and canine distemper viruses. Our analysis yielded data on viral substitution rates, the time to common ancestry, and elements of their demographic history. Estimates of rates of evolutionary change were similar to those observed in other RNA viruses, ranging from 6.585 to 11.350 x 10(-4 )nucleotide substitutions per site, per year. Strikingly, the mean Time to the Most Recent Common Ancestor (TMRCA) was both similar and very recent among the viruses studied, ranging from only 58 to 91 years (1908 to 1943). Worldwide, the paramyxoviruses studied here have maintained a relatively constant level of genetic diversity. However, detailed heterchronous samples illustrate more complex dynamics in some epidemic populations, and the relatively low levels of genetic diversity (population size) in all three viruses is likely to reflect the population bottlenecks that follow recurrent outbreaks. |
| Links |
PubMed PMC3334863 Online version:10.1007/s00239-007-9040-x |
| Keywords |
Animals; Capsid Proteins/genetics; Disease Outbreaks; Distemper Virus, Canine/genetics; Evolution, Molecular; Genetic Variation; HN Protein/genetics; Humans; Measles virus/genetics; Mumps virus/genetics; Nucleocapsid Proteins/genetics; Paramyxoviridae/classification; Paramyxoviridae/genetics; Paramyxoviridae Infections/epidemiology; Paramyxoviridae Infections/virology; Phylogeny; Selection, Genetic |
| edit table |
Significance
You can help EcoliWiki by summarizing why this paper is useful
Useful Materials and Methods
You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.
Annotations
<annotationlinks/>
EcoliWiki Links
Add links to pages that link here (e.g. gene, product, method pages)
References
See Help:References for how to manage references in EcoliWiki.