PMID:18216606
| Citation |
West, SD, Suliburk, JW, Helmer, KS and Mercer, DW (2008) Cyclooxygenase-1 suppresses lipopolysaccharide-induced changes in rat gastric inducible nitric oxide synthase. Crit. Care Med. 36:572-9 |
|---|---|
| Abstract |
Both nitric oxide synthase (NOS) and cyclooxygenase (COX) have inducible isoforms that are up-regulated during inflammatory states. However, the interaction between these enzymes is not clearly understood. The objective was to clarify the interactions between NOS and COX in the rat gastric mucosa in the presence and absence of lipopolysaccharide. |
| Links |
PubMed Online version:10.1097CCM.0B013E318162958C |
| Keywords |
Animals; Cyclooxygenase 1/physiology; Cyclooxygenase Inhibitors/pharmacology; Escherichia coli; Female; Gastric Mucosa/drug effects; Gastric Mucosa/enzymology; Gastric Mucosa/immunology; Immunity, Mucosal/drug effects; Immunity, Mucosal/physiology; Indomethacin/pharmacology; Lipopolysaccharides; Nitric Oxide Synthase Type II/metabolism; Nitrobenzenes/pharmacology; Pyrazoles/pharmacology; Rats; Rats, Sprague-Dawley; Salicylates/pharmacology; Sulfonamides/pharmacology |
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