PMID:18216606

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Citation

West, SD, Suliburk, JW, Helmer, KS and Mercer, DW (2008) Cyclooxygenase-1 suppresses lipopolysaccharide-induced changes in rat gastric inducible nitric oxide synthase. Crit. Care Med. 36:572-9

Abstract

Both nitric oxide synthase (NOS) and cyclooxygenase (COX) have inducible isoforms that are up-regulated during inflammatory states. However, the interaction between these enzymes is not clearly understood. The objective was to clarify the interactions between NOS and COX in the rat gastric mucosa in the presence and absence of lipopolysaccharide.

Links

PubMed Online version:10.1097CCM.0B013E318162958C

Keywords

Animals; Cyclooxygenase 1/physiology; Cyclooxygenase Inhibitors/pharmacology; Escherichia coli; Female; Gastric Mucosa/drug effects; Gastric Mucosa/enzymology; Gastric Mucosa/immunology; Immunity, Mucosal/drug effects; Immunity, Mucosal/physiology; Indomethacin/pharmacology; Lipopolysaccharides; Nitric Oxide Synthase Type II/metabolism; Nitrobenzenes/pharmacology; Pyrazoles/pharmacology; Rats; Rats, Sprague-Dawley; Salicylates/pharmacology; Sulfonamides/pharmacology

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