PMID:18208582

Citation	Angelone, T, Filice, E, Quintieri, AM, Imbrogno, S, Recchia, A, Pulerà, E, Mannarino, C, Pellegrino, D and Cerra, MC (2008) Beta3-adrenoceptors modulate left ventricular relaxation in the rat heart via the NO-cGMP-PKG pathway. Acta Physiol (Oxf) 193:229-39
Abstract	Using a model of isolated and Langendorff-perfused rat heart we analysed whether activation of beta3-adrenergic receptors (beta3-ARs) influences ventricular lusitropic performance. We also focused on the NOS/NO/cGMP/PKG cascade as the signal transduction mechanism.
Links	PubMed Online version:10.1111/j.1748-1716.2008.01838.x
Keywords	Adrenergic beta-Agonists/pharmacology; Adrenergic beta-Antagonists/pharmacology; Animals; Cyclic GMP-Dependent Protein Kinases/physiology; Dose-Response Relationship, Drug; Ethanolamines/pharmacology; GTP-Binding Protein alpha Subunits, Gi-Go/physiology; Isoproterenol/antagonists & inhibitors; Isoproterenol/pharmacology; Male; Nitric Oxide/physiology; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, Adrenergic, beta-3/physiology; Signal Transduction/physiology; Ventricular Function, Left/drug effects; Ventricular Function, Left/physiology
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