PMID:18208536

Citation	Lange, LA, Reiner, AP, Carty, CL, Jenny, NS, Cushman, M and Lange, EM (2008) Common genetic variants associated with plasma fibrin D-dimer concentration in older European- and African-American adults. J. Thromb. Haemost. 6:654-9
Abstract	D-dimer is a hemostasis marker that reflects ongoing fibrin formation and degradation. There is significant inter-individual and inter-population variability in D-dimer concentration, but whether genetic factors underlie these differences is largely unknown. We hypothesized that common coagulation gene variants contribute to differences in circulating D-dimer concentration.
Links	PubMed Online version:10.1111/j.1538-7836.2008.02906.x
Keywords	Africa/ethnology; African Americans/genetics; Aged; Aged, 80 and over; Blood Coagulation/genetics; Europe/ethnology; European Continental Ancestry Group/genetics; Female; Fibrin Fibrinogen Degradation Products/analysis; Fibrinogen/genetics; Fibrinolysis/genetics; Genotype; Humans; Male; Middle Aged; Plasminogen Activator Inhibitor 1/genetics; Polymorphism, Single Nucleotide; Prospective Studies; United States/epidemiology; Urokinase-Type Plasminogen Activator/genetics
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