PMID:18205290

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Citation

Wong, JV, Song, H and You, L (2008) A whole more than the sum of its synthetic parts. ACS Chem. Biol. 3:27-9

Abstract

Synthetic biology is the realization of systems with desired behavior using biological materials. A recent addition to the field is a bipartite consortium of the bacterium Escherichia coli in which each species harbors complementary gene circuits that actuate only when both are present above a critical density. This bacterial "consensus" system, functional in liquid, solid, and biofilm niches, represents a novel strategy that raises the bar in terms of the specificity and complexity of tasks performed by engineered organisms.

Links

PubMed Online version:10.1021/cb700256w

Keywords

Biofilms; Escherichia coli/genetics; Escherichia coli/physiology; Gene Expression Regulation, Bacterial; Genetic Engineering/methods; Models, Genetic

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