PMID:18198266
| Citation |
Sanders, AR, Duan, J, Levinson, DF, Shi, J, He, D, Hou, C, Burrell, GJ, Rice, JP, Nertney, DA, Olincy, A, Rozic, P, Vinogradov, S, Buccola, NG, Mowry, BJ, Freedman, R, Amin, F, Black, DW, Silverman, JM, Byerley, WF, Crowe, RR, Cloninger, CR, Martinez, M and Gejman, PV (2008) No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics. Am J Psychiatry 165:497-506 |
|---|---|
| Abstract |
The authors carried out a genetic association study of 14 schizophrenia candidate genes (RGS4, DISC1, DTNBP1, STX7, TAAR6, PPP3CC, NRG1, DRD2, HTR2A, DAOA, AKT1, CHRNA7, COMT, and ARVCF). This study tested the hypothesis of association of schizophrenia with common single nucleotide polymorphisms (SNPs) in these genes using the largest sample to date that has been collected with uniform clinical methods and the most comprehensive set of SNPs in each gene. |
| Links |
PubMed Online version:10.1176/appi.ajp.2007.07101573 |
| Keywords |
Adolescent; Adult; Catechol O-Methyltransferase/genetics; Catechol O-Methyltransferase/metabolism; Chromosome Mapping/statistics & numerical data; European Continental Ancestry Group/genetics; Female; Follow-Up Studies; Genetic Predisposition to Disease/genetics; Genetic Variation/genetics; Genotype; Haplotypes/genetics; Humans; Linkage Disequilibrium/genetics; Male; Polymorphism, Single Nucleotide; Psychotic Disorders/genetics; Psychotic Disorders/metabolism; Quality Control; Schizophrenia/genetics; Schizophrenia/metabolism |
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