PMID:18197981

Citation	Uddin, M, Opazo, JC, Wildman, DE, Sherwood, CC, Hof, PR, Goodman, M and Grossman, LI (2008) Molecular evolution of the cytochrome c oxidase subunit 5A gene in primates. BMC Evol. Biol. 8:8
Abstract	Many electron transport chain (ETC) genes show accelerated rates of nonsynonymous nucleotide substitutions in anthropoid primate lineages, yet in non-anthropoid lineages the ETC proteins are typically highly conserved. Here, we test the hypothesis that COX5A, the ETC gene that encodes cytochrome c oxidase subunit 5A, shows a pattern of anthropoid-specific adaptive evolution, and investigate the distribution of this protein in catarrhine brains.
Links	PubMed PMC2241769 Online version:10.1186/1471-2148-8-8
Keywords	Amino Acid Sequence; Animals; Base Sequence; Electron Transport Complex IV/genetics; Evolution, Molecular; Gene Expression Regulation, Enzymologic; Humans; Immunohistochemistry; Mitochondria/enzymology; Neocortex/enzymology; Open Reading Frames; Prefrontal Cortex/enzymology; Primates/genetics; Reverse Transcriptase Polymerase Chain Reaction; Species Specificity; Tissue Distribution
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