PMID:18197517

Citation	Kunii, R, Onishi, H, Ueki, K, Koyama, K and Machida, Y (2008) Particle characteristics and biodistribution of camptothecin-loaded PLA/(PEG-PPG-PEG) nanoparticles. Drug Deliv 15:3-10
Abstract	Poly(DL-lactic acid) (PLA)/poly(ethylene glycol)-block-poly (propylene glycol)-block-poly(ethylene glycol) copolymer (PEG-PPG-PEG) nanoparticles loaded with camptothecin (CPT), called CPT-NP, were prepared and examined for particle size change and drug release in phosphate-buffered saline, pH 7.4, (PBS), and drug biodistribution profiles in mice bearing sarcoma 180 solid tumor. CPT-NP kept an almost constant mean size and exhibited an initial rapid release of approximately 20%, following by very slow release. As compared with CPT solution, CPT-NP showed higher tissue accumulation and better tumor localization, which were considered essentially associated with the better efficacy of CPT-NP reported in the previous study.
Links	PubMed Online version:10.1080/10717540701827154
Keywords	Animals; Antineoplastic Agents, Phytogenic/chemistry; Antineoplastic Agents, Phytogenic/pharmacokinetics; Camptothecin/chemistry; Camptothecin/pharmacokinetics; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Drug Compounding; Hydrogen-Ion Concentration; Lactic Acid/chemistry; Male; Mice; Nanoparticles; Particle Size; Polyethylene Glycols/chemistry; Polymers/chemistry; Propylene Glycols/chemistry; Sarcoma 180/metabolism; Solubility; Tissue Distribution
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