PMID:18193106
| Citation |
Kettawan, A, Kunthida, C, Takahashi, T, Kishi, T, Chikazawa, J, Sakata, Y, Yano, E, Watabe, K, Yamamoto, Y and Okamoto, T (2007) The quality control assessment of commercially available coenzyme q(10)-containing dietary and health supplements in Japan. J Clin Biochem Nutr 41:124-31 |
|---|---|
| Abstract |
Coenzyme Q(10) (CoQ(10)) has been widely commercially available in Japan as a dietary and health supplement since 2001 and is used for the prevention of lifestyle-related diseases induced by free radicals and aging. We evaluated CoQ(10) supplements to ensure that these supplements can be used effectively and safely. Commercially available products were selected and assessed by the quality control tests specified in the Japanese Pharmacopoeia XV. When the disintegration time of CoQ(10) supplements was measured, a few tested supplements did not completely disintegrate even after incubation in water for an hour at 37 degrees C. In the content test, many samples were well controlled. However, a few supplements showed low recovery rates of CoQ(10) as compared to manufacturer's indicated contents. Among soft capsule and liquid supplements, the reduced form of CoQ(10) (H(2)CoQ(10)), as well as the oxidized form, was detected by HPLC with electrochemical detector. The results for experimental formulated CoQ(10) supplements demonstrated that H(2)CoQ(10) was produced by the interaction of CoQ(10) with vitamins E and/or C. From these results, we concluded that quality varied considerably among the many supplement brands containing CoQ(10). Additionally, we also demonstrated that H(2)CoQ(10) can be detected in some foods as well as in CoQ(10) supplements. |
| Links |
PubMed PMC2170950 Online version:10.3164/jcbn.2007017 |
| Keywords |
|
| edit table |
Significance
You can help EcoliWiki by summarizing why this paper is useful
Useful Materials and Methods
You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.
Annotations
<annotationlinks/>
EcoliWiki Links
Add links to pages that link here (e.g. gene, product, method pages)
References
See Help:References for how to manage references in EcoliWiki.