PMID:18184438
| Citation |
Faustino, RS, Behfar, A, Perez-Terzic, C and Terzic, A (2008) Genomic chart guiding embryonic stem cell cardiopoiesis. Genome Biol. 9:R6 |
|---|---|
| Abstract |
Embryonic stem cells possess a pluripotent transcriptional background with the developmental capacity for distinct cell fates. Simultaneous expression of genetic elements for multiple outcomes obscures cascades relevant to specific cell phenotypes. To map molecular patterns critical to cardiogenesis, we interrogated gene expression in stem cells undergoing guided differentiation, and defined a genomic paradigm responsible for confinement of pluripotency. |
| Links |
PubMed PMC2395240 Online version:10.1186/gb-2008-9-1-r6 |
| Keywords |
Animals; Embryonic Stem Cells/cytology; Embryonic Stem Cells/metabolism; Gene Expression Profiling; Gene Regulatory Networks; Mice; Myocytes, Cardiac/cytology; Systems Biology |
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