PMID:18182619
| Citation |
Gray, MJ, Van Buren, G, Dallas, NA, Xia, L, Wang, X, Yang, AD, Somcio, RJ, Lin, YG, Lim, S, Fan, F, Mangala, LS, Arumugam, T, Logsdon, CD, Lopez-Berestein, G, Sood, AK and Ellis, LM (2008) Therapeutic targeting of neuropilin-2 on colorectal carcinoma cells implanted in the murine liver. J. Natl. Cancer Inst. 100:109-20 |
|---|---|
| Abstract |
Neuropilin-2 (NRP2) is a high-affinity kinase-deficient receptor for vascular endothelial growth factor (VEGF) and semaphorin 3F. We investigated its function in human colorectal cancers. |
| Links |
PubMed Online version:10.1093/jnci/djm279 |
| Keywords |
Animals; Apoptosis/drug effects; Carcinoma/drug therapy; Carcinoma/metabolism; Cell Hypoxia/drug effects; Cell Movement/drug effects; Cell Proliferation/drug effects; Cell Survival/drug effects; Colorectal Neoplasms/drug therapy; Colorectal Neoplasms/metabolism; Disease Progression; Gene Expression Regulation, Neoplastic/drug effects; HCT116 Cells; Humans; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Liposomes; Liver Neoplasms, Experimental/drug therapy; Liver Neoplasms, Experimental/metabolism; Mice; Neoplasm Invasiveness; Neuropilin-2/genetics; Neuropilin-2/metabolism; Proto-Oncogene Proteins c-akt/metabolism; RNA, Small Interfering/pharmacology; RNA, Small Interfering/therapeutic use; Reverse Transcriptase Polymerase Chain Reaction; Semaphorins/metabolism; Signal Transduction/drug effects; Transfection; Transplantation, Heterologous; Vascular Endothelial Growth Factor A/metabolism; Vascular Endothelial Growth Factor Receptor-1/metabolism |
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