PMID:18058563

Citation	Peng, CG and Damha, MJ (2007) DNA polymerase recognition of 2'-deoxy-2'-fluoroarabinonucleoside 5'-triphosphates (2'F-araNTPs). Nucleosides Nucleotides Nucleic Acids 26:1189-93
Abstract	We examined the ability of 2'-deoxy-2'-fluroarabinonucleoside 5'-triphosphates (2'F-araNTPs) to serve as substrates of various DNA polymerases. In addition, we also examined the ability of these polymerases to accept DNA-FANA (2'-deoxy-2'-fluoroarabinonucleic acids) chimeras as template strands while synthesizing a DNA or FANA-DNA complementary strand. We provide preliminary data demonstrating that 2'F-araNTPs are indeed substrates of several DNA polymerases, and that FANA-DNA chimeric templates are generally well recognized by these polymerase enzymes.
Links	PubMed Online version:10.1080/15257770701527786
Keywords	Arabinonucleotides/chemistry; Arabinonucleotides/metabolism; Base Sequence; DNA Primers; DNA-Directed DNA Polymerase/metabolism; SELEX Aptamer Technique; Substrate Specificity
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