PMID:18058541

Citation	Alexandrova, LA, Ivanov, MA, Victorova, LS and Kukhanova, MK (2007) Furano- and pyrrolo [2,3-d] pyrimidine nucleosides and their 5'-O-triphospates: synthesis and enzymatic activity. Nucleosides Nucleotides Nucleic Acids 26:1083-6
Abstract	A series of bicyclic [2,3-d]furano- and pyrrolopyrimidine ribonucleosides were synthesized and converted chemically into corresponding 5'-O-triphosphates. Substrate properties of the triphosphates toward some RNA and DNA polymerases are reported.
Links	PubMed Online version:10.1080/15257770701516250
Keywords	Animals; Antiviral Agents/chemical synthesis; Antiviral Agents/chemistry; Antiviral Agents/metabolism; Antiviral Agents/pharmacology; Bicyclo Compounds/chemical synthesis; Bicyclo Compounds/chemistry; Bicyclo Compounds/metabolism; Cattle; DNA-Directed DNA Polymerase/metabolism; DNA-Directed RNA Polymerases/metabolism; Drug Design; HIV Reverse Transcriptase/antagonists & inhibitors; Hepacivirus/drug effects; Hepacivirus/enzymology; Molecular Structure; Pyrimidine Nucleosides/chemical synthesis; Pyrimidine Nucleosides/chemistry; Pyrimidine Nucleosides/metabolism; Pyrimidine Nucleosides/pharmacology; Pyrimidine Nucleotides/chemical synthesis; Pyrimidine Nucleotides/chemistry; Pyrimidine Nucleotides/metabolism; Pyrimidine Nucleotides/pharmacology; Substrate Specificity
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