PMID:18058538

Citation	Liu, X, Inomata, M, Ogawara, T, Saneyoshi, M and Yamaguchi, T (2007) Telomere shortening in human HL60 cells by treatment with 3'-azido-2',3'-dideoxynucleosides and telomerase inhibition by their 5'-triphosphates. Nucleosides Nucleotides Nucleic Acids 26:1067-71
Abstract	Telomerase is thought to play an important role in the mechanism of tumor cell immortalization by maintenance of telomere length. To obtain information on the susceptibility of telomerase to nucleoside analogues, the effects of base-modified 3'-azido-2',3'-dideoxynucleoside triphosphates on the enzyme were investigated. It is suggested that the 2-amino group of the nucleotide purine nucleus is important for the inhibitory activity. Telomere shortening caused by long-term treatment with these nucleosides is also described.
Links	PubMed Online version:10.1080/15257770701515468
Keywords	Dideoxyadenosine/analogs & derivatives; Dideoxyadenosine/chemistry; Dideoxyadenosine/pharmacology; Dideoxynucleosides/chemistry; Dideoxynucleosides/pharmacology; Dideoxynucleotides/chemistry; Dideoxynucleotides/pharmacology; Drug Design; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/pharmacology; HL-60 Cells; Humans; Telomerase/antagonists & inhibitors; Telomere/drug effects
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