PMID:18048679

Citation	Trinkle-Mulcahy, L and Lamond, AI (2007) Toward a high-resolution view of nuclear dynamics. Science 318:1402-7
Abstract	The nucleus is the defining feature of eukaryotic cells. It is a highly dynamic, membrane-bound organelle that encloses chromatin and thereby partitions gene transcription from sites of protein translation in the cytoplasm. Major cellular events, including DNA replication, messenger RNA synthesis and processing, and ribosome subunit biogenesis, take place within the nucleus, resulting in a continuous flux of macromolecules into and out of the nucleus through dedicated nuclear pore complexes in the nuclear envelope. Here, we review the impact of new technologies, especially in areas of fluorescence microscopy and proteomics, which are providing major insights into dynamic processes affecting both structure and function within the nucleus.
Links	PubMed Online version:10.1126/science.1142033
Keywords	Active Transport, Cell Nucleus; Animals; Cell Nucleolus/physiology; Cell Nucleolus/ultrastructure; Cell Nucleus/physiology; Cell Nucleus/ultrastructure; Cell Nucleus Structures/physiology; Cell Nucleus Structures/ultrastructure; Microscopy, Fluorescence; Mitosis; Nuclear Envelope/physiology; Nuclear Envelope/ultrastructure; Nuclear Pore/physiology; Nuclear Pore/ultrastructure; Nuclear Proteins/physiology; Proteomics
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