PMID:18042279
| Citation |
Priya, B, Premanandh, J, Dhanalakshmi, RT, Seethalakshmi, T, Uma, L, Prabaharan, D and Subramanian, G (2007) Comparative analysis of cyanobacterial superoxide dismutases to discriminate canonical forms. BMC Genomics 8:435 |
|---|---|
| Abstract |
Superoxide dismutases (SOD) are ubiquitous metalloenzymes that catalyze the disproportion of superoxide to peroxide and molecular oxygen through alternate oxidation and reduction of their metal ions. In general, SODs are classified into four forms by their catalytic metals namely; FeSOD, MnSOD, Cu/ZnSOD and NiSOD. In addition, a cambialistic form that uses Fe/Mn in its active site also exists. Cyanobacteria, the oxygen evolving photosynthetic prokaryotes, produce reactive oxygen species that can damage cellular components leading to cell death. Thus, the co-evolution of an antioxidant system was necessary for the survival of photosynthetic organisms with SOD as the initial enzyme evolved to alleviate the toxic effect. Cyanobacteria represent the first oxygenic photoautotrophs and their SOD sequences available in the databases lack clear annotation. Hence, the present study focuses on structure and sequence pattern of subsets of cyanobacterial superoxide dismutases. |
| Links |
PubMed PMC2234264 Online version:10.1186/1471-2164-8-435 |
| Keywords |
Amino Acid Sequence; Anabaena/enzymology; Binding Sites; Conserved Sequence; Cyanobacteria/enzymology; Hydrogen Bonding; Iron/chemistry; Iron/metabolism; Manganese/chemistry; Manganese/metabolism; Models, Molecular; Nickel/chemistry; Nickel/metabolism; Sequence Alignment; Structural Homology, Protein; Superoxide Dismutase/chemistry; Superoxide Dismutase/classification; Superoxide Dismutase/genetics; Superoxide Dismutase/metabolism |
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