PMID:18039828
| Citation |
Zoetendal, EG, Smith, AH, Sundset, MA and Mackie, RI (2008) The BaeSR two-component regulatory system mediates resistance to condensed tannins in Escherichia coli. Appl. Environ. Microbiol. 74:535-9 |
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| Abstract |
The gene expression profiles of Escherichia coli strains grown anaerobically with or without Acacia mearnsii (black wattle) extract were compared to identify tannin resistance strategies. The cell envelope stress protein gene spy and the multidrug transporter-encoding operon mdtABCD, both under the control of the BaeSR two-component regulatory system, were significantly up-regulated in the presence of tannins. BaeSR mutants were more tannin sensitive than their wild-type counterparts. |
| Links |
PubMed PMC2223256 Online version:10.1128/AEM.02271-07 |
| Keywords |
Drug Resistance, Bacterial/genetics; Escherichia coli/drug effects; Escherichia coli/genetics; Escherichia coli/physiology; Escherichia coli Proteins/genetics; Escherichia coli Proteins/physiology; Gene Expression Regulation, Bacterial/drug effects; Genes, Bacterial; Oligonucleotide Array Sequence Analysis; Operon; Periplasmic Proteins/genetics; Periplasmic Proteins/physiology; Reverse Transcriptase Polymerase Chain Reaction; Tannins/pharmacology |
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