PMID:17937820

Citation	McLaughlin, WA, Chen, K, Hou, T and Wang, W (2007) On the detection of functionally coherent groups of protein domains with an extension to protein annotation. BMC Bioinformatics 8:390
Abstract	Protein domains coordinate to perform multifaceted cellular functions, and domain combinations serve as the functional building blocks of the cell. The available methods to identify functional domain combinations are limited in their scope, e.g. to the identification of combinations falling within individual proteins or within specific regions in a translated genome. Further effort is needed to identify groups of domains that span across two or more proteins and are linked by a cooperative function. Such functional domain combinations can be useful for protein annotation.
Links	PubMed PMC2151957 Online version:10.1186/1471-2105-8-390
Keywords	Algorithms; Amino Acid Motifs/physiology; Databases, Genetic; Databases, Protein/trends; Forecasting; Pattern Recognition, Automated/methods; Protein Binding; Protein Conformation; Protein Interaction Mapping/methods; Protein Structure, Tertiary/physiology; Proteins/chemistry; Proteins/classification; Proteins/ultrastructure; Proteomics/methods; Saccharomyces cerevisiae/chemistry; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/ultrastructure; Saccharomyces cerevisiae Proteins/chemistry; Saccharomyces cerevisiae Proteins/classification; Saccharomyces cerevisiae Proteins/ultrastructure; Sequence Alignment; Sequence Analysis, Protein; Structural Homology, Protein; Structure-Activity Relationship; Terminology as Topic
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