PMID:17877616

Citation	Li, NF, Broad, S, Lu, YJ, Yang, JS, Watson, R, Hagemann, T, Wilbanks, G, Jacobs, I, Balkwill, F, Dafou, D and Gayther, SA (2007) Human ovarian surface epithelial cells immortalized with hTERT maintain functional pRb and p53 expression. Cell Prolif. 40:780-94
Abstract	Cell immortalization is considered to be a prerequisite status for carcinogenesis. Normal human ovarian surface epithelial (OSE) cells, which are thought to be the origin of most of human ovarian carcinomas, have a very limited lifespan in culture. Establishment of immortalized OSE cell lines has, in the past, required inactivation of pRb and p53 functions. However, this often leads to increased chromosome instability during prolonged culture.
Links	PubMed Online version:10.1111/j.1365-2184.2007.00462.x
Keywords	Cadherins/genetics; Cell Cycle; Cell Line; Cyclin-Dependent Kinase Inhibitor p15/genetics; Epithelial Cells/cytology; Epithelial Cells/metabolism; Female; Gene Expression Profiling; Genes, Retinoblastoma; Genes, p53; Humans; In Situ Hybridization, Fluorescence; Ovary/cytology; Ovary/metabolism; RNA, Messenger/genetics; RNA, Messenger/metabolism; Receptor, Macrophage Colony-Stimulating Factor/genetics; Retinoblastoma Protein/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Telomerase/genetics; Telomerase/metabolism; Tumor Suppressor Protein p53/metabolism
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